Q When carcinoma of stomach develops secondarily to pernicious anemia, it is usually situated in the:
A. Prepyloric region
B. Pylorus
C. Body
D. Fundus
Explanation
Correct Answer :- D. Fundus
(Sleisenger & Fordtrans text book of Gastroinstestinal disease 7th/813)
Pernicious anemia is associated with autoimmune atrophic gastritis affecting the fundic glands. Intestinal metaplasia
(premalignant for gastric carcinoma), is characteristically seen in this area of atrophic gastritis. Atrophic glands with ex￾tensive intestinal metaplasia are most characteristically confined to the fundus in patients with pernicious anemia.
A. Prepyloric region B. Pylorus C. Body D. Fundus Explanation
Correct Answer :- D. Fundus
(Sleisenger & Fordtrans text book of Gastroinstestinal disease 7th/813)
Pernicious anemia is associated with autoimmune atrophic gastritis affecting the fundic glands. Intestinal metaplasia
(premalignant for gastric carcinoma), is characteristically seen in this area of atrophic gastritis. Atrophic glands with ex￾tensive intestinal metaplasia are most characteristically confined to the fundus in patients with pernicious anemia.